Speaker Cabs for recording - how many woofers?

Curious to get people's opinion on this:

I'm looking to get a couple different guitar/bass speaker cabs for recording studio use, and I'm wondering if anyone has any thoughts/feelings/preferences for single-woofer cabinets (like a 1x12") vs. multi-woofer cabinets (like a 4x12"). All else being equal, do you find it represents a significant difference in tone?

My technical brain tells me the extra woofers might cause weird phase issues, but maybe that's a non-issue, or maybe even contributes to a typical "good" guitar sound. Opinions?