Poor Sleep Quality Accelerates Brain Aging

A large-scale study tracking more than 27,500 middle-aged and elderly people over roughly nine years has found that poor sleep quality is associated with accelerated brain aging, and chronic inflammation appears to be one of the key mechanisms driving this effect.

Researchers at Sweden's Karolinska Institute assessed participants' sleep across five dimensions -- chronotype, duration, insomnia, snoring and daytime sleepiness -- and later scanned their brains using MRI to estimate biological brain age through machine learning models. The results? For every point decrease in healthy sleep score, the gap between brain age and chronological age widened by approximately six months. Those in the poorest sleep category had brains that appeared roughly one year older than their actual age.

Night-owl tendencies, sleep duration outside the 7-8 hour sweet spot and snoring were particularly strongly linked to brain aging. The researchers measured low-grade inflammation using biomarkers including C-reactive protein levels and white blood cell counts. Inflammation accounted for more than 10% of the association between poor sleep patterns and brain aging. The glymphatic system, which clears waste from the brain primarily during sleep, may also play a role, the research added.

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