Our Preoccupation With Protein Intake

A review of published meta-analyses examining protein supplementation found no evidence supporting intake beyond 1.6 grams per kilogram of body weight daily, according to an analysis by cardiologist Eric Topol. The review examined multiple randomized controlled trials encompassing thousands of participants. The most widely cited Morton study, which included 1,863 participants across 49 trials, showed no statistically significant benefit at higher protein levels, with a p-value of 0.079.

Recent research from Washington University identified the essential amino acid leucine as activating mTOR in macrophages, promoting atherosclerosis progression. The mechanism was demonstrated in both mouse models and human studies measuring circulating monocyte changes following acute high-protein challenges increasing dietary protein from 22% to 50% of energy intake. Current USDA data indicates 55% of American men and 35% of women already exceed the 0.8 g/kg/day recommendation from the National Academy of Medicine. The protein supplement industry, exemplified by David bars containing 28 grams of protein in 150 calories using a modified plant fat called EPG, projects $180 million in 2025 sales.

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