Technology For Lab-Grown Eggs Or Sperm On Brink of Viability, UK Watchdog Finds

An anonymous reader quotes a report from The Guardian: Bolstered by Silicon Valley investment, scientists are making such rapid progress that lab-grown human eggs and sperm could be a reality within a decade, a meeting of the Human Fertilization and Embryology Authority board heard last week (PDF). In-vitro gametes (IVGs), eggs or sperm that are created in the lab from genetically reprogrammed skin or stem cells, are viewed as the holy grail of fertility research. The technology promises to remove age barriers to conception and could pave the way for same-sex couples to have biological children together. It also poses unprecedented medical and ethical risks, which the HFEA now believes need to be considered in a proposed overhaul of fertility laws.

Peter Thompson, chief executive of the HFEA, said: 'In-vitro gametes have the potential to vastly increase the availability of human sperm and eggs for research and, if proved safe, effective, and publicly acceptable, to provide new fertility treatment options for men with low sperm counts and women with low ovarian reserve.' The technology also heralds more radical possibilities including 'solo parenting' and 'multiplex parenting.' Julia Chain, chair of HFEA, said: 'It feels like we ought to have Steven Spielberg on this committee,' in a brief moment of levity in the discussion of how technology should be regulated. Lab-grown eggs have already been used produce healthy babies in mice -- including ones with two biological fathers. The equivalent feat is yet to be achieved using human cells, but US startups such as Conception and Gameto claim to be closing in on this prize.

The HFEA meeting noted that estimated timeframes ranged from two to three years -- deemed to be optimistic -- to a decade, with several clinicians at the meeting sharing the view that IVGs appeared destined to become 'a routine part of clinical practice.' The clinical use of IVGs would be prohibited under current law and there would be significant hurdles to proving that IVGs are safe, given that any unintended genetic changes to the cells would be passed down to all future generations. The technology also opens up myriad ethical issues. Thompson said: 'Research on IVGs is progressing quickly but it is not yet clear when they might be a viable option in treatment. IVGs raise important questions and that is why the HFEA has recommended that they should be subject to statutory regulation in time, and that biologically dangerous use of IVGs in treatment should never be permitted.'

'This is the latest of a range of detailed recommendations on scientific developments that we are looking at to future-proof the HFE Act, but any decisions around UK modernizing fertility law are a matter for parliament.'

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