Eating Less Can Lead To a Longer Life: Massive Study in Mice Shows Why

Cutting calorie intake can lead to a leaner body -- and a longer life, an effect often chalked up to the weight loss and metabolic changes caused by consuming less food. Now, one of the biggest studies of dietary restrictions ever conducted in laboratory animals challenges the conventional wisdom about how dietary restriction boosts longevity. From a report: The study, involving nearly 1,000 mice fed low-calorie diets or subjected to regular bouts of fasting, found that such regimens do indeed cause weight loss and related metabolic changes. But other factors -- including immune health, genetics and physiological indicators of resiliency -- seem to better explain the link between cutting calories and increased lifespan. 'The metabolic changes are important,' says Gary Churchill, a mouse geneticist at the Jackson Laboratory in Bar Harbor, Maine, who co-led the study. 'But they don't lead to lifespan extension.'

To outside investigators, the results drive home the intricate and individualized nature of the body's reaction to caloric restriction. 'It's revelatory about the complexity of this intervention,' says James Nelson, a biogerontologist at the University of Texas Health Science Center in San Antonio. The study was published today in Nature by Churchill and his co-authors, including scientists at Calico Life Sciences in South San Francisco, California, the anti-ageing focused biotech company that funded the study. Scientists have long known that caloric restriction, a regimen of long-term limits on food intake, lengthens lifespan in laboratory animals. Some studies have shown that intermittent fasting, which involves short bouts of food deprivation, can also increase longevity.

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