Groundbreaking Trial To Grow 'Mini Liver' From Patient's Own Lymph Node

An anonymous reader quotes a report from InterestingEngineering: A Pittsburgh-based biotech company has started a one-of-a-kind trial in a patient with a failing liver. Their goal is to grow a functional second liver within the patient's body -- something never achieved before. If effective, it might be a life-saving therapy for those who require liver transplants but have to wait months for a compatible donor organ. LyGenesis is currently carrying out a trial in only one patient with end-stage liver disease (ESLD) to test the efficacy of their allogenic regenerative cell therapy. As per Nature, the experimental procedure was conducted in Houston on March 25. The report also states that the patient is 'recovering well' after receiving the treatment. However, the formation of the new liver-like organ in the lymph node may take several months. Moreover, the individual will be kept on immunosuppressive drugs to prevent any initial rejection of the donor cells. The physicians will continue to monitor the patient's health closely.

In this trial, scientists prepared donated hepatocyte cells for transplantation by suspending them in a solution. These cells were then transplanted into the patient's upper abdominal lymph nodes, which are tiny bean-shaped structures. These structures are an essential immune system component and filter waste from the body. Apart from the abdomen, lymph nodes are also found in the neck and chest. The team opted for a minimally invasive approach to inject the cells into the patient's lymph node via a catheter in the neck. 'The lymph nodes then act as in vivo bioreactors, helping the hepatocytes to engraft, proliferate, and generate functional ectopic liver tissue,' the press release noted. In simplest terms, these cells have the ability to multiply over the next several months. In a person with a failing liver, lymph nodes might operate as a second liver-like organ.

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