A Third Person May Have Been Cured of HIV

An anonymous reader quotes a report from New Scientist: Following news of a man in the UK who has been free of HIV since his cancer treatment, a similar case has been reported by researchers who treated a patient in Germany. Together, they add to evidence that it may be possible to cure HIV. The virus infects cells of the immune system, which are made in the bone marrow. A man known as the 'Berlin patient' was the first person to become HIV-free after cancer treatment, back in 2007. To treat his leukemia -- a cancer of the immune system -- he was given a treatment that involved killing nearly all his immune cells with radiotherapy or drugs, and then replacing them with cells from a donor. This donor was naturally resistant to HIV, thanks to a rare but natural mutation in a gene called CCR5.

A possible third case was then announced today, at the Conference on Retroviruses and Opportunistic Infections in Seattle. Biopsies from the gut and lymph nodes of this 'Dusseldorf patient' show no infectious HIV after three months off antiviral drugs -- only old fragments of viral genes that wouldn't be able to multiply, says Annemarie Wensing of University Medical Center Utrecht in the Netherlands, who worked on this case. This is just like the Berlin and London patients, she says. Researchers are tracking the few other people who have HIV and have then had a bone marrow transplant from someone with the CCR5 mutation in a collaboration called IciStem. As well as the three reported so far, there are two others who haven't yet stopped taking antiviral medications, says Javier Martinez-Picado of the IrsiCaixa AIDS Research Institute in Barcelona.

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