How Llamas Could Help Us Fight the Flu

An anonymous reader quotes a report from PBS: Researchers now think they're on the path to a new kind of flu protection -- one that might last longer and work against all types of influenza viruses. The source of their new defense: llamas. These furry South American mammals produce special antibodies -- molecules that mark foreign invaders in our bodies for destruction -- that can identify a huge range of elusive influenza viruses. A new study used these antibodies to target multiple strains of influenza at once, a technique that could lead to more effective flu prevention. These antibodies can survive without refrigeration for longer, which could reduce the cost and complexity of flu treatment.

The researchers behind Thursday's study fused four different single-domain antibodies into one larger molecule, held together with a human protein as a scaffold. When they injected this hybrid into mice, the antibodies kept the animals safe from a wide variety of influenza type A and type B viruses -- the two most common assailants in America's annual flu epidemic. This hybrid seemed to successfully target each of the five flu strains they tested. When the researchers injected mice with their hybrid antibody, it protected the mice from lethal doses of the flu. But the paper also explored another route of delivery: gene therapy. The researchers used a benign virus -- dubbed AAV -- to embed the genetic blueprint of the llama antibodies directly into mouse cells. This procedure allowed the mice to produce the antibodies on their own.

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