Scientists Have Made a Human Microbiome From Scratch

To better understand how microbes affect our health, researchers combined 119 species of bacteria naturally found in the human body. From a report: Our bodies are home to hundreds or thousands of species of microbes -- nobody is sure quite how many. That's just one of many mysteries about the so-called human microbiome. Our inner ecosystem fends off pathogens, helps digest food and may even influence behavior. But scientists have yet to figure out exactly which microbes do what or how. Many studies suggest that many species have to work together to do each of the microbiome's jobs.

To better understand how microbes affect our health, scientists have for the first time created a synthetic human microbiome, combining 119 species of bacteria naturally found in the human body. When the researchers gave the concoction to mice that did not have a microbiome of their own, the bacterial strains established themselves and remained stable -- even when the scientists introduced other microbes. The new synthetic microbiome can even withstand aggressive pathogens and cause mice to develop a healthy immune system, as a full microbiome does.

The findings were published on Tuesday in the journal Cell. A better understanding of the microbiome could potentially lead to a powerful way to treat a host of diseases. Already, doctors can use the microbiome to treat life-threatening gut infections of the bacteria Clostridium difficile. They just have to transplant stool from a healthy donor, and the infection usually goes away.

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