Gel That Repairs Heart Attack Damage Could Improve Health of Millions

British researchers have developed a biodegradable gel to repair damage caused by a heart attack in a breakthrough that could improve the health of millions of survivors worldwide. The Guardian reports: Now after years of efforts searching for solutions to help the heart repair itself, researchers at the University of Manchester have created a gel that can be injected directly into the beating heart -- effectively working as a scaffold to help injected cells grow new tissue. Until now, when cells have been injected into the heart to reduce the risk of heart failure, only 1% have stayed in place and survived. But the gel can hold them in place as they graft on to the heart.

To prove the technology could work, researchers showed the gel can support growth of normal heart muscle tissue. When they added human cells reprogrammed to become heart muscle cells into the gel, they were able to grow in a dish for three weeks and the cells started to spontaneously beat. Echocardiograms (ultrasounds of the heart) and electrocardiograms (ECGs, which measure the electrical activity of the heart) on mice confirmed the safety of the gel. To gain more knowledge, researchers will test the gel after mice have a heart attack to show they develop new muscle tissue. The study is being presented at the British Cardiovascular Society conference in Manchester.

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