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Molecules Produced By Gut Bacteria Could Help the Human Body Fight Cancer

Wednesday July 14, 2021. 09:00 AM , from Slashdot
The molecules produced by stomach bacteria could give the human body a helping hand when it comes to the immune system, even going so far as to help fight tumors. ScienceAlert reports: 'The results are an example of how metabolites of intestinal bacteria can change the metabolism and gene regulation of our cells and thus positively influence the efficiency of tumor therapies,' says immunologist Maik Luu from University Hospital Wurzburg in Germany. Short chain fatty acids (SCFAs) are one of the helpful molecules produced when dietary fiber is fermented in the gut. Major SCFAs are acetate and butyrate, along with the less common pentanoate, found only in some bacteria. All of these SCFAs have a bunch of positive health effects in humans, such as the regulation of insulin resistance, cholesterol, and even appetite. Luu and colleagues have now found that butyrate and pentanoate also boost the anti-tumor activity of a type of killer T cell known as CD8, by reprogramming the way they work. For the first time, they have experimentally demonstrated this in mice.

Using lab mice, the team found that certain commensal bacteria produce pentanoate. For example, one relatively rare human gut bacterium, Megasphaera massiliensis, enhanced small proteins called cytokines in the killer T cells, leading to an increased ability to destroy tumor cells. As a control, the team experimented with other, non-pentanoate producing bacteria and found no effect on the cytokine levels. This finding could be particularly useful for therapies that leverage the immune system to fight cancer. Some tumor cells have proteins on their surfaces that can bind to proteins on T cells, resulting in an immune 'checkpoint' response which tells the killer cell to spare its target -- in this case, the cancer cell. Immune checkpoint inhibitor (ICI) therapy works by blocking these checkpoint proteins, allowing the T cells to do their job and destroy the tumor cells. The team also looked at a genetically modified type of T cell called CAR-T cells which are used in immunotherapy, and found that the bacterial assistance worked the same way, particularly on solid tumors. The research has been published in Nature Communications.

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